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Thymosin beta-4 (often written as T4 or TB4) is a naturally occurring peptide, and TB-500 (or fequesetide) is a synthetic peptide based on a segment of TB4.3 4 While TB4 is made up of 43 amino acids, TB-500 contains only seven.4 5 Sometimes, especially in earlier research, you may see TB-500 referred to by its amino acid sequence, Ac-LKKTETQ.6 Insider Tip: The Ac- before amino acid sequences, like those of peptides, means its been permanently modified with an added acetyl group a process called N-terminal acetylation to protect it from degradation.7 8 This can improve a peptides stability,9 bioavailability,10 and other properties.11 Though nearly all synthetic peptides are protected in one way or another during synthesis, this protection is usually reversible
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Inhibition of tumor growth against chemoresistant cholangiocarcinoma by a proapoptotic peptide targeting interleukin-4 receptor
doi: 10.1016/S0024-3205(97)00744-3
